Protein Details: Aquaporin-0
Protein ID
ICDB_Pro_0050
Protein Name
Aquaporin-0
Gene Name
MIP
Organism
Oryctolagus cuniculus (Rabbit)
Length
263 amino acids
AlphaFoldDB
AF-A4L9J0-F1-model_v4.pdb
Function
Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity).
Sequence
MWELRSASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYMAAQLLGAVAGAAVLYSVTPAAVRGNLALNTLHPGVSLGQATTVEIFLTLQFVLCIFATYDERRNGRLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPIIGGGLASLLYDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL
PDB Structures
Ligand Binding
Binding Site
SITE 149: "Important for water channel gating"; SITE 246: "Interaction with BFSP1"; SITE 250: "interaction with BFSP1";
Disease
Location
DOI ID
RefSeq
NP_001093431.1